Chondroitin sulphate competitively inhibits degredative enzymes of proteoglycans in cartilage and synovial fluid.
Glucosamine has been found to possess antiinflammatory activity in different animal models without inhibiting the synthesis of prostaglandin. Its primary mode of action is stimulating the manufacture of substances necessary for joint synthesis.
Sulphur is a key player in the formation and fortification of joint cartilage. The basic molecules that form joint cartilage are long chains of
glycosaminoglycans that are linked together by string bonds between two sulphur atoms that reduce flexibility of the chains, and makes cartilage firm and resilient.
For sulphur to enter the body, it is thought to pass through the digestive wall where it is incorporated into serum proteins, but for this to occur, it needs to be present in simple organic molecules, such as MSM.